Showing posts with label promote. Show all posts
Showing posts with label promote. Show all posts
Saturday, April 23, 2016
Accelerated Satellite Muscle Precursor Cell Proliferation is Yet Another Way for Whey to Promote Muscle Gains
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When the satellite cells merge with the existing muscle cells to form new myonuclei this is more than muscle repair, its also the foundation for future muscle growth - beyond previous limits | more |
I dont want to go into more detail, here. If you want to develop a better understanding of this process(es), I suggest you head back to the initially mentioned series about the physiological underpinnings of skeletal muscle hypertrophy.
You can learn more about protein intake at the SuppVersity

Are You Protein Wheysting?

5x More Than the FDA Allows!

Wheys to Build Muscle W/ Cardio
High EAA protein for fat loss
Fast vs. slow protein

Less Fat, More Muscle!
According to a recent study from the Aarhus University all it takes to help your muscle precursor cells happily proliferating (grow, divide and mature to "real" muscle cells) is the mix of carbohydrates and whey protein youre probably consuming after each workout, anyway: A shake containing 28 g whey protein hydrolysate high in leucine (4 %) an 28 g of carbohydrate (4 %) - a 56h carbohydrate supplement served as control.
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Figure 1: Overview of the experimental procedure (Farup. 2014) |
Its the whey that does the trick, but we dont know if we dont need CHOs as an adjunct
The provision of extra whey protein (but nor carbohydrates; white bars in Figure 2) lead to significant increases in satellite cell activity in both mixed muscle and type II fibers, but not type I fibers (not shown in Figure 2).
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Figure 2: Number of satellite cells per muscle fiber (higher number = higher chance of incorporation; Farup. 2014) |
High volume increases satellite cell activity, as well | read more |
What I would like to know, though, is whether there are hormonal changes involved, as well. What about IGF-1, for example? As youve read in the initially cited series about building muscle, the latter, or rather its splice variants, appear heavily involved in the structural super-compensation effects that facilitate future gains in skeletal muscle mass. Or whether the effects of whey isolate, concentrate and hydrolysate (used in the study) differ (if its IGF, hydrolysate should be most potent, because its most insulinogenic).
Alas, I guess, we will have to wait for future studies to elucidate these "secrets", in the mean time, I will stick to my whey isolate + concentrate mixes. Why? Well, money and taste are worth considering, as well... especially if you guesstimate the advantage of the bad tasting highly expensive hydrolysate to be as negligible, as I do.
- Farup, et al. "Whey protein supplementation accelerates satellite cell proliferation during recovery from eccentric exercise." Amino Acids (2014). Ahead of print.
Friday, March 4, 2016
Protein Blends Not Isolates Promote Maximal Skeletal Muscle Protein Retention ! Its Not About How Much You Pump into the Muscle Its About How Much You Retain
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Scientific evidence suggests: There is not one optimal protein to build muscle - its the mix of fast to slow proteins thats key. |
You can learn more about protein intake at the SuppVersity

Are You Protein Wheysting?
Cod protein for recovery

Protein requ. of athletes
High EAA protein for fat loss
Fast vs. slow protein

5x More Than FDA Allows
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Figure 1: Graphical overview of the study design (Reidy. 2014) |
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Figure 2: Net phenylalanine enrichment (left) and inward and outward transport (right) |
"However, the ingestion of the protein blend resulted in a prolonged and positive net phenylalanine balance during postexercise recovery compared with whey protein (P 0.05)." (Reidy)In view of identical postexercise myofibrillar protein synthesis in both groups this difference may appear negligible. If youve been following my articles about the often oversimplified protein synthesis and increases in skeletal muscle mass, you should be aware that net retention and not fractional synthesis is the term you have to look for, when youre analyzing corresponding studies.
Bolus ingestion could be a superior alternative: In view of the fact that the advantage of protein blends is directly related to their ability to trigger sustained increases of the level of amino acids in the blood, the same can be achieved by the ingestion of whey protein at regular intervals - e.g. at least every 2 hours. Needless to say that this is not just more expensive, but also less practical than the 20-40g of a protein blend many of you are probably already consuming right after their workouts.
Bottom line: I am still very hesitant to suggest buying a blend with significant amounts of soy in it, when egg proteins should do a similarly beneficial job as a "filler" that keeps the amino acids (AA) levels elevated when the influx of AAs from whey is beginning to seize and the slow digesting casein protein (in the study at hand, we had regular sodium caseinate, which is actually faster digesting than micellar casein) are not yet fully digested.
In general, however, the study at hand clearly supports the notion that protein blends that are designed to provide a sustained elevation of all essential amino acids in the blood (not just BCAAs, learn why) will induce a superior growth response. Whether the same is true if we compare the ingestion of a single protein blend shake to the repeated (ev. 2h) ingestion of 20g of whey protein, will yet have to be elucidated in future studies.
In general, however, the study at hand clearly supports the notion that protein blends that are designed to provide a sustained elevation of all essential amino acids in the blood (not just BCAAs, learn why) will induce a superior growth response. Whether the same is true if we compare the ingestion of a single protein blend shake to the repeated (ev. 2h) ingestion of 20g of whey protein, will yet have to be elucidated in future studies.
- Reidy, Paul T., et al. "Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle." Journal of Applied Physiology 116.11 (2014): 1353-1364.
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