Showing posts with label cell. Show all posts
Showing posts with label cell. Show all posts

Saturday, April 23, 2016

Accelerated Satellite Muscle Precursor Cell Proliferation is Yet Another Way for Whey to Promote Muscle Gains

When the satellite cells merge with the existing muscle cells to form new myonuclei this is more than muscle repair, its also the foundation for future muscle growth - beyond previous limits | more
If youve read the Intermittent Thoughts On Building Muscle (read it) you are beyond the simplistic view of muscle growth as a one-way process in the course of which muscle cells balloon up endlessly. Without the incorporation of "new" myonuclei (cell kernels) from the periphery your muscle would become dysfunctional sooner or later (learn more); and while myostatin will prevent that from happening the recruitment of new muscle cells from the satellite cell pool will provide the basis for future muscle growth.

I dont want to go into more detail, here. If you want to develop a better understanding of this process(es), I suggest you head back to the initially mentioned series about the physiological underpinnings of skeletal muscle hypertrophy.
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Next to the inclusion of new myonuclei and facilitation of future muscle growth, the satellite cell pool will also provide the raw material for the repair or I should say replacement of damaged muscle cells. For strength trainees like you and me, its thus of paramount importance to ensure that our satellite cells are happy and healthy. And you know what? Thats not even difficult!

According to a recent study from the Aarhus University all it takes to  help your muscle precursor cells happily proliferating (grow, divide and mature to "real" muscle cells) is the mix of carbohydrates and whey protein youre probably consuming after each workout, anyway: A shake containing 28 g whey protein hydrolysate high in leucine (4 %) an 28 g of carbohydrate (4 %) - a 56h carbohydrate supplement served as control.
Figure 1: Overview of the experimental procedure (Farup. 2014)
As you can see in Figure 1 this supplement was not ingested once, but rather thrice a day - with the first serving being ingested immediately after the fasted subjects, 24 healthy young recreational active men,  initiated the exercise protocol, which lasted for approximately 30 min.

Its the whey that does the trick, but we dont know if we dont need CHOs as an adjunct

The provision of extra whey protein (but nor carbohydrates; white bars in Figure 2) lead to significant increases in satellite cell activity in both mixed muscle and type II fibers, but not type I fibers (not shown in Figure 2).
Figure 2: Number of satellite cells per muscle fiber (higher number = higher chance of incorporation; Farup. 2014)
Still, in view of the fact that regeneration is an energetically costly process, its not 100% certain that a certain amount of carbohydrates may be necessary to see the beneficial effects on satellite cell activity and the changes in maximal voluntary contraction force (not shown).
High volume increases satellite cell activity, as well | read more
Bottom line: I know that you dont really need another reason to supplement with whey protein. I am also aware that the result, as new as they may be, will not make whey protein more efficient that it already is.

What I would like to know, though, is whether there are hormonal changes involved, as well. What about IGF-1, for example? As youve read in the initially cited series about building muscle, the latter, or rather its splice variants, appear heavily involved in the structural super-compensation effects that facilitate future gains in skeletal muscle mass. Or whether the effects of whey isolate, concentrate and hydrolysate (used in the study) differ (if its IGF, hydrolysate should be most potent, because its most insulinogenic).

Alas, I guess, we will have to wait for future studies to elucidate these "secrets", in the mean time, I will stick to my whey isolate + concentrate mixes. Why? Well, money and taste are worth considering, as well... especially if you guesstimate the advantage of the bad tasting highly expensive hydrolysate to be as negligible, as I do.
Reference:
  • Farup, et al. "Whey protein supplementation accelerates satellite cell proliferation during recovery from eccentric exercise." Amino Acids (2014). Ahead of print.


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Friday, April 8, 2016

Type Multiple Lines in a Cell in Excel


How to Type Multiple Lines in a Single Cell in Excel


Excel users often face a common problem. Normally you cant type two or three words in a cell in Microsoft Excel. You have to merge cells to type something. But if you have no option to merge cell horizontally then you may fall in trouble. Believe it or not, last week I had the same problem while working in a worksheet! 


Today I am sharing the solution with you. Look at the image below - 


Multiple Lines in a Row


By default, you cant type like the image above in MS Excel. Have you noticed - I havent merge the rows or colums. And there are 3 lines in Column A and 4 lines in Column B. Try to type multiple lines in a row or cell. Simply you cant. You have to use the Wrap Text option to type multiple lines in a cell. 



For Excel 2003

Sorry to say, I dont have Microsoft Office 2003. So I cant show you the path. Probably you have to follow this way- 

Format Menu > Font > Format Cells > Alignment > Text Control > Wrap Tex (Check the box) > OK. 

Im not sure about this command. But the main point is - find the format cells window and then check the wrap text from alignment tab. 

You can also press Shift + Ctrl + F to open Fomat Cells dialogue box. 



For Excel 2007 and 2010

In Excel 2007 or 10, the process is almost same. But as you have to use the ribbon interface, you have to follow this way - 


Wrap Text Under Alignment in Home Tab


Go to the Home Tab > Click on the Marked area of Alignment > Now you will get Format Cells window (Shift + Ctrl + F) > Choose Alignment tab > Check the Wrap text option > Hit OK. 



Shortcut Method!

Maybe its very time consuming for you. Im gonna share a secret shortcut! 

Type your text in cell, when the area ends, press Alt+Enter. You will get a new line in cell! See the image below: 


Multipe Lines in a Row


First Ive typed Marks PC, then I pressed Alt+Enter and typed Solution. But remember, first you have adjust the column size. Adjust the column size and then type your text. Once you press Alt+Enter, new lines will be creating automaticlly when the cell area ends. 


There is another shortcut for you! Just look at the image below:


Wrap Text Icon in Home Tab

Have you noticed the market button? Its in the Alignment section, just below the Review Tab. This button is a shortcut to wrap text. Type your text and hit on this button to create multiple lines in a row/ cell. 


You can adjust the column size after typing the text. Your lines will be adjusted automatically. 


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