Showing posts with label antioxidant. Show all posts
Showing posts with label antioxidant. Show all posts
Sunday, April 3, 2016
The Overlooked Non ROS Scavenging Antioxidant Effects of Creatine Monohydrate CM Works W W Out Exercise
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Creatine, obviously monohydrate and no expensive and often impotent spinoff (Jäger. 2011) is useful for any athlete. |
You can learn more about creatine at the SuppVersity

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Build Ur Own Buffered Creatine
"to evaluate the effects of monohydrate creatine supplementation associated, or not, with RT on oxidative stress and antioxidant enzymatic activity in the plasma, the heart, the liver and the gastrocnemius of rats." (Stefani. 2014)And the results were unambiguous. As you can see in Figure 1, the anti-oxidant capacity of plasma, heart and liver of all 40 male Wistar rats which had been divided into four groups, i.e.
- sedentary (SED),
- sedentary + creatine (SED-Cr), and
- resistance training (RT) and resistance training + creatine (RT-Cr),
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Figure 1: Oxidative stress in heart, liver and muscle after 8 weeks of intervention.Concentrations of MDA and CAT activity. Values are mean ± SD; n = 10 for all groups (Stefani. 2014). |
Works w/ and w/out exercise, but with the latter creatine really excels
Compared to the sedentary animals the rats in the exercise group did yet significantly increased catalase levels (=good, because it catalyzes the decomposition of hydrogen peroxide - the bad stuff - to water and oxygen - the benign stuff) in the heart and - obviously - increased strength gains.
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Figure 2: Absolute and relative 1RM strength before and after the intervention (Stefani. 2014). |
If you look closely, you will yet realize that the relative increase in strength, a much better gauge for lasting real-world strength gains, in the sedentary rodents was ZERO. So that it is very likely that they would disappear with the increased water the rats were holding, as soon as the creatine supplementation is seized.
If you want to make your creatine even better, super-charge it with baking soda (NaHCO3) and build your own "buffered" creatine | learn more |
I mean, what other invalid reason for not making use of this "non-enzymatic antioxidant" as a side-effect free health and performance promoter?
- Jäger, Ralf, et al. "Analysis of the efficacy, safety, and regulatory status of novel forms of creatine." Amino Acids 40.5 (2011): 1369-1383.
- Stefani, Giuseppe Potrick, et al. "Effects of creatine supplementation associated with resistance training on oxidative stress in different tissues of rats." Journal of the International Society of Sports Nutrition 11.1 (2014): 11.
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Thursday, March 31, 2016
Physical Cognitive Exercise Are Similarly Effective DNA Protectors Antioxidant Boosters in Elderly Men Women
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Brain builders and muscle builders are similarly effective DNA protectors in the elderly. |
DNA damage is obviously important, maintaining optimal lean mass levels is important, too

Tri- or Multi-Set Training for Body Recomp.?
Alternating Squat & Blood Pressure - Productive?
Pre-Exhaustion Exhausts Your Growth Potential
Full ROM ? Full Gains - Form Counts!
Battle the Rope to Get Ripped & Strong
Study Indicates Cut the Volume Make the Gains!
In the recent Austrian study, the subjects had been randomized to three groups. The previously described cognitive training group, which also served as a "control", as well as two resistance training groups.
Tri- or Multi-Set Training for Body Recomp.?

Alternating Squat & Blood Pressure - Productive?

Pre-Exhaustion Exhausts Your Growth Potential

Full ROM ? Full Gains - Form Counts!

Battle the Rope to Get Ripped & Strong

Study Indicates Cut the Volume Make the Gains!
"The RT groups (RT and RTS) performed two sessions of RT per week, supervised by a sport scientist, conducted on two non-consecutive days. Training attendance was recorded every session. The only equipment used was exercise bands and a chair. [...] The main part consisted of 10 exercises for the main muscle groups (legs, back, abdomen, chest, shoulder and arms). One training session started with 10 min of warm-up, continued with 3040 min of strength training and ended with a 10-min cool-down. To keep the training stimulus high enough, the exercise program was adjusted to the participants individual needs, by either adapting the resistance of the elastic band (shorter or stronger band) or by modifying the exercise, by means of performing a more diffiult version. In the initial phase (4 weeks) one set of 15 repetitions was performed in order to learn the correct form of each exercise. From the fifth week on, the intensity and volume were progressively increased from two sets of light exercises to two sets of heavy resistance. If the participants could easily perform two sets of 15 repetitions they were told either to take more resistance or to perform a more difficult version of the exercise" (Franzke. 2014).In contrast to the RT group, which did "nothing", but the previously described resistance training regimen, the subjects in the RTS group consumed a multi-ingredient supplement every morning, as well as directly after each training session. Said supplement consisted of 20.7g protein [56 energy (En) %, 19.7g whey protein, 3 g leucine, >10 g essential amino acids], 9.3 g carbohydrates (25 En%, 0.8 BE); 3.0 g fat (18 En%), 1.2 g roughage (2 En%), 800 IU (20 ?g) of vitamin D, 250 mg calcium, vitamins C, E, B6 and B12, folic acid and magnesium (one portion FortiFit, Nutricia with a total energy content per drink of only 150 kcal).
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Figure 1: Changes in parameters of DNA damage and antioxidant enzyme expression (Franzke. 2014). |
We should keep in mind, though, that (a) non-significant benefits were visible for the formamidopyrimidine DNA glycosylase (FPG) and the expression of superoxide dismutase and that (b) the actual benefits of protein supplements would have become visible only if the scientists had accessed the changes in body composition, as well.
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Maximal protein synthesis - How much protein do the elderly need? Find out in a previous SV article. |
All Christmas jokes aside, the study at hand simply confirms what the proverb "a rolling stone gathers no moss" implies. Exercise, no matter whether its cognitive or physical exercise, protects aging men and women from pro-cancerous DNA damage and ensures that can maintain "a sound mind in a sane body" | Comment on Facebook!
- Franzke, B. et al. "The impact of six months strength training, nutritional supplementation or cognitive training on DNA damage in institutionalised elderly." Mutagenesis (2015):147153.
Monday, February 29, 2016
Study Puts Behind Beneficial Health Effects of Veggies! Is There No Correlation Between Antioxidant Content Beneficial Health Effects of Cucumber Lotus Rape!
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Dont obsess about "optimal" antioxidant contents, just eat your veggies! |
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"Skin of Grape Tomatoes Contains Max. Amount of Antioxidants" - You can find this and dozens of other daily updated SuppVersity Science News on www.facebook.com/SuppVersity |
If the results of the study can be confirmed by an independent team for vegetables other than lotus root, rape or cucumber and if there is an identical mismatch between the in-vivo anti-oxidant capacity and the potential benefits in improving antioxidant function in (aged) humans.
This would be big and highly consequential news for nutrition experts, scientists and average Joes and Janes like you and me. Why? Well,...
- any ranking of "superfoods" that was based even partly on in vitro data derived with the good old ferric reducing antioxidant power (FRAP) assay would be invalid, ...
- every scientist who has been following up on "promising" data from FRAP assays would have been wasting his time, ...
- and you may have been eating all the wrong foods for years...
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Figure 1: FRAP value, vitamin C and vitamin E content and total amount phenolics in the powdered vegetables that were added to the rodent diets in the study at hand (Ji. 2014) |
Never forget the three principles of veggie eating: Variety, seasonality, colorfulness
Against that background Id recommend you keep eating your lotus roots, if you like them, although, they have a significantly lower beneficial effect on SuperOxide Dismutase (SOD, a group of antioxidant enzymes) than rape and cucumber.
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Figure 2: Serum markers of anti-oxidant status / oxidative damage after 6 weeks on the three experimental diets (Ji. 2014) |
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Figure 3: Blood mononuclear cell DNA damage expressed as total injury rate (%) and total tails low (% of all) in male Wistar rats on control and experimental diets (Ji. 2014) |
Trust your instincts and go for a broad variety of vegetables. Eat seasonal! Eat colorful! And most importantly eat plenty. Optimal or not, none of the vegetables in the study at hand would harm you - all of them would help you defy diabesity and slow the aging process as best mother nature allows.
- Ji, Linlin, et al. "No correlation is found for vegetables between antioxidant capacity and potential benefits in improving antioxidant function in aged rats." Journal of Clinical Biochemistry and Nutrition 54.3 (2014): 198-203.
- Levine, Rodney L. "Carbonyl modified proteins in cellular regulation, aging, and disease2, 3." Free Radical Biology and Medicine 32.9 (2002): 790-796.
- Valdez-Morales, Maribel, et al. "Phenolic content, and antioxidant and antimutagenic activities in tomato peel and seeds, and tomato by-products." Journal of Agricultural and Food Chemistry (2014). Accepted Manuscript.
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